High plasma viscosity symptoms8/2/2023 Retinopathy and visual derangements such as blurred vision or double vision arise because of microvascular changes such as thrombosis or hemorrhage. These neurological manifestations are due to decreased blood flow to the central nervous system and deposition of paraproteins within the myelin sheath of peripheral nerves. ![]() Neurological findings can include a headache, neuropathic syndromes, generalized stupor, coma, dizziness, ataxia, hearing impairment, seizures, and stroke syndromes. The clinical triad of mucosal or skin bleeding, neurological deficits, and visual disturbances suggests HVS however, a variety of end-organ damages can also be observed as the initial presenting symptom.īleeding is the most common manifestation and typically arises from impaired platelet function resulting in oozing mucosal surfaces like epistaxis, bleeding gums, or gastrointestinal (GI) bleeding. During history taking, it is important to note any current or past hematological disorders as well as any family history of such conditions. The level of viscosity at which symptoms can initially present is variable from person to person depending on the underlying physiology, but for a given patient, symptoms will typically manifest about the same level of viscosity over time.Ī high degree of clinical suspicion is required based on history and physical exam findings to diagnose HVS. The severity of clinical symptoms is directly related to the increased levels of serum viscosity, with progressively more severe symptoms occurring as the individual patient’s serum viscosity increases. An increase in circulating proteins can also affect platelet aggregation and cause prolonged bleeding time. This increase in viscosity causes sluggish blood flow, relative decreased microvascular circulation, and hypoperfusion of tissues. This includes RBC, WBC, platelets, or serum proteins. An increase in blood viscosity can be caused either by a deformity of the shape of red blood cells (RBCs) which causes RBC aggregation and decreased blood flow or by any pathological elevation of the components of blood. HVS is the pathological condition in which blood is "thicker" than normal and therefore flow is reduced. Viscous fluids are thicker and travel more slowly. ![]() When fluid has low viscosity, it travels quickly and without much difficulty. Viscosity is formally defined as the measurement of the internal resistance of a fluid to flow but can simply be thought of as the "thickness" or "stickiness" of a fluid.
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